The main obstacles for adopting a mobile health information system to existing hospital information system are the redundancy of clinical data and the additional workload for implementing the new system. To obtain a seamless communication and to reduce the workload of implementation, an easy and simple implementation strategy is required. We propose a mobile clinical information system (MobileMed) which is specially designed for the easy implementation. The key elements of MobileMed are a smart interface, an HL7 message server, a central clinical database (CCDB), and a web server. The smart interface module transfers the key information to the HL7 message server as new clinical tests data is recorded in the existing laboratory information system. The HL7 message server generates the HL7 messages and sends them to the CCDS. As a central database the CCDS collects the HL7 messages and presents them to the various mobile devices such as PDA. Through this study we might conclude that the architecture for the mobile system will be efficient for real-time data communication, and the specially designed interface will be an easy tool for implementing the mobile clinical information system.