In this paper we consider an optimal configuration problem for redundant inertial sensors which have uncertainty such as misalignment, scale factor error. The optimal configuration problem is treated from the viewpoint of navigation accuracy. We propose a necessary and sufficient condition for the optimal configuration of redundant sensors with no uncertainty, and a sufficient condition for the optimal configuration of redundant sensors with uncertainty. Finally we propose a condition for the optimal configuration based both navigation performance and FDI(fault detection and isolation).