It is over 100 years after Lee Je Ma has proposed concept of the Sasang constitutional medicine in his book DongEuiSooSeBoWon in 1894. As well known, this concept describes four constitution of Taeyang, Taeum, Soyang, and Soeum which are deals with physical body status and shape, desease and symptoms, personal characters, and organ function. In these days there are growing needs to elucidate this Sasang concept by the scientific manner, especially by biological tools. However there are no genes revealed related to the Sasang and moreover it is not easy to give a biological evidence for the Sasang constitution. Here are some considerations about the brief history of biological research on the Sasang constitution, and some prospectives of how to do to find genes of Sasang, and which to be done for what is about Sasang.