Purpose: The purpose of this study was to determine the effect of an education program promoting safety knowledge and safety practice for mothers with infants. Method: This education was provided at two public health centers in Kyunggi Province. A non-equivalent control group pretest-post test design was used, and the participants were 95 mothers in the experimental group, and 44 mothers in the control group. Data were collected using a questionnaire, and were analyzed with the SPSS program. Results: After the group education sessions on safety management at the public health centers, the mean scores for knowledge and practice of safety in the experimental group were significantly higher than that of mothers in the control group mothers. Also, after the safety education, mothers in the experimental group perceived a higher priority in safety in child care than they had before the education program. Conclusion: The education for mothers with infants regarding the child safety was effective in promoting knowledge and practice of safety for infants.