The 40\% of wall thickness criterion which has been used as a plugging rule of steam generator tubes is applicable only to a single cracked tube. In the previous studies performed by authors, several global failure prediction models were introduced to estimate the failure loads of steam generator tubes containing two adjacent parallel axial through-wall cracks. These models were applied for thin plates with two parallel cracks and the COD base model was selected as the optimum one. The objective of this study is to verify the applicability of the proposed optimum global failure prediction model for real steam generator tubes with two parallel axial through-wall cracks. For the sake of this, a series of plastic collapse tests and finite element analyses have been carried out fur the steam generator tubes with two machined parallel axial through-wall cracks. Thereby, it was proven that the proposed optimum failure prediction model can be used as the best one to estimate the failure load quite well. Also, interaction effects between two adjacent cracks were assessed through additional finite element analyses to investigate the effect on the global failure behavior.