This paper is concerned with the theoretical treatment of transient thermal stresses involving an orthotropic functionally graded thick strip due to nonuniform heat supply in the width direction. The thermal and thermoelastic constants of the strip are assumed to possess orthotropy and vary exponentially in the thickness direction. The transient two-dimensional temperature is analyzed by the methods of Laplace and finite sine transformations. We obtain the exact solution for the simply supported strip under the state of plane strain. Some numerical results for the temperature change, the displacement and the stress distributions are shown in figures. Furthermore, the influence of the orthotropy and nonhomogeneity of the material is investigated.