Wind-induced mean and dynamic interference effects of tall buildings are studied in detail by a series of wind tunnel tests in this paper. Interference excitations of several types of upwind structures of different sizes in different upwind terrains are considered. Comprehensive interference characteristics are investigated by artificial neural networks and correlation analysis. Mechanism of the wakes vortex-induced resonance is discussed, too. Measured results show significant correlations exist in the distributions of the interference factors of different configurations and upwind terrains and, therefore, a series of relevant regression equations are proposed to simplify the complexity of the multi-parameter wind induced interference effects between two tall buildings.