Based on the test data of Nippon Steel Corporation, the formulas for calculating mechanical properties of fire-resistant (FR) steel at elevated temperatures have been established. A practical approach for fire safety design of FR steel members, including axially compressed members, flexural members and eccentrically compressed members, is developed in this paper. Compared with the full-scale specimen experiments and FEM numerical analysis, this practical approach for fire safety design of FR steel members is demonstrated to be effective and precise.