Coexistence of different wireless systems that share the 2.4 GHz ISM frequency band is becoming one of the most important issue. This paper presents a model of the interference that IEEE 802.11b affected by IEEE 802.15.4. The packet error rate (PER) of IEEE 802.11b under the interference of IEEE 802.15.4 is analyzed. The PER is obtained by using the bit error rate (BER) and the collision time. Further, this paper suggests a packet length to reduce the effect of the IEEE 802.15.4 interference and obtain a maximum throughput of the IEEE 802.11b. The analytical results are validated using simulation.