Purpose: The purpose of this study is to examine the factors surrounding burnout of nurses caring for cancer patients. Methods: The sample of this study was conveniently selected among nurses who had hospice care experiences working in General Hospitals located in Seoul. This study was conducted by a self-administered questionnaire. Two hundred forty four questionnaires were retrieved and the response rate was 81.3%. The period of data collection was from February 25th to March 5th in 1994. Mean, standard deviation, T-test ANOVA, and multiple regression analysis were performed for statistical analysis. Results: The data showed that respondents reported to have burnout as many as 2.71 out of a 5.0 score. Bivariate analyses indicated that those who had hospice education reported to have a lower burnout than those without hospice education. Multivariate regression analyses revealed factors associated with burnout the nurses have had. They include being a Christian, higher job satisfaction, and experiences of hospice education. Hospice education reducing burnout for the nurses was observed by hierarchial multiple regression analyses, after controlling out the effect of coping methods, sociodemographic characteristics, job satisfaction, and job-related stresses on experience of burnout. This observation was not hue for physical and psychological burnout but for burnout in general and emotional one. But this was not confirmed among the nurses with type A personality. Conclusion: The findings of this study have a weakness in generalizability due to the sampling methodology used in this study. However, for the better hospice care further research with a probability sampling method are necessary.