Today, the sciences in medical and nursing fields are becoming progressively more dependent on electrical apparatus for the preservation of life of hospitalized patients. Therefore, it is required more safety medical power distribution system in order to protect patients and physicians more securely from unexpected leakage of current. Especially for the medically used rooms which use life sustaining equipment power should be provided as supplying continuously without interrupting with lowest leakage current. This thesis proposed the reason why Isolation Power System is safety through the circuit analysis and applications.