Purpose: The purpose of this study was to identify the relationship among self-leadership, job satisfaction, and perceived outcome in nurses. Method: The subjects of study were nurses as a population who were working for the 2 of university hospitals which have over 500 beds in Kyong Ki Province as well as who have been working for over 6 months. The data was collected by questionnaires from 217 nurses and analyzed using descriptive statistics, pearson correlation coefficient, and multiple regression on SPSS 10. 0 version. Results: The degree of Self-leadership was 3.38 out of 5 as a mean point. There was a significant difference in self-leadership according to age, level of education, working department, and position. There was a significant positive correlation between self-relationship and job satisfaction, self-relationship and perceived outcome, and job satisfaction and perceived outcome. The stepwise multiple regression analysis revealed that the most powerful predictor of job satisfaction and perceived outcome was constructive thinking. Conclusion: In conclusion, the result was obtained that self-leadership is much correlated with job-satisfaction of nurse and outcome of nursing practice. Therefore, as a way to promote efficiency of nursing organization, the constant study about self-leadership with the various aspects is needed focusing on self-management and inner motivation as a new leadership paradigm.