Response Surface Method (RSM) constructs approximate response surfaces using sample data from experiments or simulations and finds optimum levels of process variables within the fitted response surfaces of the interest region. It will be necessary to get the most suitable response surface for the accuracy of the optimization. The application of RSM plan experimental designs. The RSM is used in the sequential optimization process. The first goal of this study is to improve the plan of central composite designs of experiments with various locations of axial points. The second is to increase the optimal efficiency applying a modified method to update interest regions.