The NP-hard channel assignment problem becomes more and more important to use channels as efficiently as possible because there is a rapidly growing demand and the number of usable channel is very limited. The hybrid genetic and local search (HGLS) method in this paper is a hybrid method of genetic algorithm with no interference channel assignment (NICA) in clustering stage for diversified search and local search in tuning stage when the step of search is near convergence for minimizing blocking calls. The new representation of solution is also proposed for effective search and computation for channel assignment.