The exhaust system of automobile is faced with random or spectrum types of fatigue loads during usage life and so needs to be closely estimated for quality and performance to have enough certainty on design endurance lift during preliminary design process. Structural operation conditions, operation load history, property of material and manufacturing process etc. should be considered by performing experiment approach. Using the software program for predicting fatigue life quickly and exactly in preliminary design stage saves plenty of time and cost generated by fatigue tests. In this paper, fatigue life prediction was performed on the basis of fatigue analysis using MSC/FATIGUE and load data from field test and the life of development items was estimated and compared through the results.