In this paper, we present the design and implementation of an agent knowledge and QoS tuning methodology to improve the flexibility of agent-based flexible video-conference system. In order to improve the flexibility during video-conferencing, we propose a new T-INTER(Tuning-INTER) architecture of knowledge part in video-conference manager (VCM) agent in which an automatic QoS parameter tuning method is imbedded. The flexible video-conference system structured based on the proposed architecture can cope with the changes in service quality required by users. The VCM agent cooperates with other agents by protocols and executes the automatic QoS parameter tuning task whenever needed. By the tuned parameters, the system is able to flexibly cope with the internal or external changes and the burden of users can be decreased. In the experimental section, it is shown that our proposed system outperforms the existing system.