Prestressed concrete girder(PSC girder) bridges have been used widely at the railway as well as highway because they are great in the functional and economical efficiency. Also they have the advantage of convenience of design and construction. However it could be easily verified that the section of PSC girder is excessive design, which has much redundancy against design loads. Thus, in this paper the formulation of the optimum design for PSC girder railway bridge is suggested and dominant design variables and constraints are inquired as performing the optimum design. In order to effective optimum design, design variables are formulated as PSC girder sectional dimension and girder space. The objective is adopted as total cost of PSC girder railway bridge. Also, constraints are formulated according to Korean railway design specification and considering construction-ability such as PS anchorage and girder space. Using the proposed optimum design system, optimum PSC girder railway bridge design has been performed. And from the results of analysis it is suggested to denote the optimum section which satisfies the structural safety and economical efficiency all together,