The importance of atmospheric conditions for the assessment of an air pollution situation has been demonstrated by their influence on the various compartments of an air pollution system, comprising all stages from emission to effects. Especially, air pollutants dispersion phenomenon are very sensitive according to wind data. But the discussions of how to apply representative meteorological data in air pollution dispersion model are not frequent in Korean environmental assessment processes. In this study, we investigated the difference of air pollutants dispersion phenomenon using U.S EPA ISCLT3 model according to applying the different meteorological data observed at two points for Seongseo industrial complex of Daegu. Two points are the spot site of Seongseo industrial complex and Daegu meteorological observatory. The winds speed of the spot site were smaller than those of Daegu meteorological observatory. In the winter season, the differences came to about $64\%$ for the period$(I;February;2001~31;January;2002)$. Wind directions were also fairly different at two points. The air pollutants dispersion phenomenon estimated from our numerical experiments were also fairly different owing to the meteorological conditions at two points.