Thermal neutrality is not enough to achieve thermal comfort. The temperature level can be the optimal, and still people may complain. This situation is often explained by the problem of local discomfort. Local discomfort can be caused by radiant asymmetry, local air velocities, too warm and too cold floor temperature and vertical temperature difference. This temperature difference may generate thermal discomfort due to different thermal sensation in different body parts. Therefore, thermal comfort can not be correctly evaluated without considering these differences. This study investigates thermal discomfort sensations of different body parts and its effect on overall thermal sensation and comfort in air-heating room. Experimental results of evaluating thermal discomfort at different body parts in an air-heating room showed that thermal sensation on the shoulder was significantly related to the overall thermal sensation and discomfort. Although it is known that cool-head, warm-foot condition is good for comfort living, cool temperature around the head generated discomfort.