In this study, the ventilation performance of mechanical ventilation system in apartment House was analyzed through model test according to characteristics of air-vent. Then adequate interval of air-vent was suggested using computer simulation which will create comfort environment through improvement of ventilation performance in apartment house. The result of experiment with separation plate to prevent mixture of contaminated exhaust air with fresh supply air, the ventilation efficiency improved about 10%. The result of simulation with horizontal location of exterior air-vent, contaminated exhaust air is mixed regardless of interval variation. Consequently, mixture of the exhaust air can be prevented through locating the supply air vent on the top side and exhaust air vent on the lower side.