Objectives : The study was peformed to evaluate the effect of treatment for Osteoarthritis of knee joint by using Homnis Placenta Herbal Acupuncture. Methods : We investigated 60 cases of patient with Osteoarthritis of knee joint from 1st February 2005 to 31st January 2005, 60 cases of patient with Osteoarthritis in knee joint treated at the department of acupuncture & moxibustion of Kwang-Dong Oriental Medicine Hospital were randomly selected for two group. One group was treated by Homnis Placenta Herbal Acupuncture therapy, the other group was treated by Filiform Acupuncture therapy. We studied Lyshoim score, Ahlaback Grade, Nine-point scale and improvement degree of the grade of Ahlaback. Results : 1. In the Lyshoim score, Homnis Filiform Acupuncture was more effective than Filiform Acupuncture. But, there was no significance between two groups statistically in the Lyshoim score. 2. In the Nine point score, Homnis Placenta Herbal Acupuncture was more effective than Filiform Acupuncture. 3.In the improvement degree of the grade of Ahlaback., Homnis Placenta Herbal Acupuncture was as effective as Filiform Acupuncture. Conclusion : In the treatment of Osteoarthritis of knee joint, Homnis Placenta Herabl Acupuncture was not more effective than Filiform Acupuncture statistically. But both Homnis Placenta Herbal Acupuncture and Piliform Acupuncture was effective in Osteoarthritis of knee joint.