The importance of measurement of health-related quality of life (HRQL) cannot be overemphasized. However, efforts to implement HRQL measurement often fail because of differences in definition and insufficient information about available measures. In this paper, many available HRQL measures are reviewed, which have been designed for, or frequently used with, people with cancer in order to aid in the evaluation of effects of oriental medicine on cancer patients. A total of 28 articles were selected from three different databases. The selected articles were analyzed according to three aspects of application of the Korean version of HRQL measures, namely generic, disease specific and symptoms related instruments. Nine HRQL measures are completed with Korean validation and data collection under contact and permission of the author. However, research studies that reported data on quality of life (QOL) in cancer patients treated with oriental medicine were wholly lacking. It is recommended that further studies be performed, using methods of data collection whose validity and reliability has been confirmed.