기관회원 [로그인]
소속기관에서 받은 아이디, 비밀번호를 입력해 주세요.
개인회원 [로그인]

비회원 구매시 입력하신 핸드폰번호를 입력해 주세요.
본인 인증 후 구매내역을 확인하실 수 있습니다.

회원가입
서지반출
흰쥐의 위(胃) 배출능(排出能)에 대한 반하사심탕(半夏瀉心湯)의 효능(效能)
[STEP1]서지반출 형식 선택
파일형식
@
서지도구
SNS
기타
[STEP2]서지반출 정보 선택
  • 제목
  • URL
돌아가기
확인
취소
  • 흰쥐의 위(胃) 배출능(排出能)에 대한 반하사심탕(半夏瀉心湯)의 효능(效能)
  • Effect of Banhasasimtang Granule on Gastric Emptying in Rats
저자명
이준석,김진성,류봉하,윤상협,Lee. Joon-Suk,Kim. Jin-Sung,Ryu. Bong-Ha,Yoon. Sang-Hyub
간행물명
대한한방내과학회지
권/호정보
2006년|27권 2호|pp.471-479 (9 pages)
발행정보
대한한방내과학회
파일정보
정기간행물|
PDF텍스트
주제분야
기타
이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

Backgrounds & Objectives: Banhasasimtang granule(BHSST) has been used for the treatment of functional dyspepsia regarded as one of the gastric dysmotility disease. but its mechanisms of action are not well known yet: So we investigated the effects of BHSST on gastric emptying and its mechanisms of action in rats. Methods: Gastric emptying was measured by glass beads(1mm in diameter) expelled from the stomach for 60 min after administration of normal saline(NS) or BHSST 31mg/kg or 93mg/kg in rats. And by the same method gastric emptying was measured after administration of NS or BHSST 93mg/kg in rats treated with atropine sulfate(1mg/kg, s.c.), quinpirol HCI(0.3mg/kg, i.p.), NAME(NG-nitro-L-arginine methyl ester, 75mg/kg, s.c.) or cisplatin(10mg/kg, i.p.) to make delayed gastric emptying. Results: BHSST 93mg/kg improved gastric emptying more than NS or BHSST 31mg/kg(p=0.016). Under the delayed gastric emptying, BHSST 93mg/kg improved gastric emptying in the group treated with NAME$(5.00{pm}3.101;vs;9.00{pm}3.51,;p;=0.046)$, but aggravated it With atropine sulfate$(5.71{pm}3.45;vs;2.57{pm}1.62,;p;=0.050)$ and cisplatin$(12.7{pm}2.29;vs;8.57{pm}5.06,;p;=0.072)$. Conclusions: BHSST improves the gastric emptying through cholinergic and 5-hydroxytryptamine 3 receptors. Especially it is effective to improve gastric emptying delayed by NAME. So we expect that it would be effective in functional dyspepsia with impaired reservoir functions such as gastric adaptive relaxation.