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알러지성 비염 병태 모델에 대한 방풍통성산(防風通聖散)의 항알러지 효과
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  • 알러지성 비염 병태 모델에 대한 방풍통성산(防風通聖散)의 항알러지 효과
저자명
김희정,박외숙,김규석,차재훈,김윤범,Kim. Hee-Jeong,Park. Owe-Suk,Kim. Keoo-Seok,Cha. Jae-Hoon,Kim. Yoon-Bum
간행물명
韓方眼耳鼻咽喉皮膚科學會誌
권/호정보
2006년|19권 1호|pp.21-30 (10 pages)
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대한한방안이비인후피부과학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Background and Objective : Allergic rhinitis is a IgE-mediated hypersensitive reaction at nasal mucosa. In oriental medicine, Bangpungtongsung-San is clinically widely used for the treatment of the allergic rhinitis. The objective of this study is to investigate the effects of Bangpungtongsung-San on allergic rhinitis experimentally. Material and Methods : BALB/c mouse were divided into there groups: intact, control, experimental groups. Control and experimental group were induced allergic rhinitis by Ovalbumin as· the method of Levin and Vaz. Experimental group was orally administered the Bangpungtongsung-San for 28days. Total IgE, Interleukin-4, Interleukin-5 and $Interferon-{gamma}$ were measured at three groups. The statistical significance was examined by Independent Samples T test. Results : 1. The experimental group shows increase of $IFN-{gamma}$ by 17% compared with control group but there was no statistical significance. 2. The experimental group shows increase of IL-4 and IL-5 compared with control group but there was no statistical significance. 3. The experimental group shows increase of Total IgE and diminution of OVA-specific IgE by 32% compared with control group but there was no statistical significance. Conclusion : The effect of Bangpungtongsung-San on allergic rhinitis is not immunological but seems to be anti-imflammatory and anti-stress effect.