The quality of precision spindle units (S/Us) running on rolling bearings depends strongly on their structural parameters, such as the configuration and geometry of the S/U elements and bearing preloads. When S/Us are designed, their parameters should be optimized to improve the performance characteristics. However, it is practically impossible to state perfectly a general criterion function for S/U quality. Therefore, we propose to use a multicriteria optimization based on the parameter space investigation (PSI) method We demonstrate the efficiency of the proposed method using the optimization results of high-speed S/Us.