Nucleocapsid Amino Acids 211 to 254, in Particular, Tetrad Glutamines, are Essential for the Interaction Between the Nucleocapsid and Membrane Proteins of SARS-Associated Coronavirus

Nucleocapsid Amino Acids 211 to 254, in Particular, Tetrad Glutamines, are Essential for the Interaction Between the Nucleocapsid and Membrane Proteins of SARS-Associated Coronavirus
Nucleocapsid Amino Acids 211 to 254, in Particular, Tetrad Glutamines, are Essential for the Interaction Between the Nucleocapsid and Membrane Proteins of SARS-Associated Coronavirus

ㆍ 저자명: Fang. Xiaonan,Ye. Lin-Bai,Zhang. Yijuan,Li. Baozong,Li. Shanshan,Kong. Lingbao,Wang. Yuhua,Zheng. Hong,Wang. Wei,Wu. Zhenghui
ㆍ 간행물명: The journal of microbiology
ㆍ 권/호정보: 2006년|44권 5호|pp.577-580 (4 pages)
ㆍ 발행정보: 한국미생물학회
ㆍ 파일정보: 정기간행물|ENG|
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ㆍ 주제분야: 기타

이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.

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기타언어초록

GST pull-down assays were used to characterize the SARS-CoV membrane (M) and nucleocapsid (N) interaction, and it was found that the amino acids 211-254 of N protein were essential for this interaction. When tetrad glutamines (Q) were replaced with glutamic acids (E) at positions of 240-243 of the N protein, the interaction was disrupted.

키워드

SARS-CoV membrane protein nucleocapsid protein M-N interaction GST pull-down assay

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