This paper presents an efficient input variable selection method using both fixed-point independent component analysis(FP-ICA) and adaptive partition mutual information(AP-MI) estimation. FP-ICA which is based on secant method, is applied to quickly find the independence between input variables. AP-MI estimation is also applied to estimate an accurate dependence information by equally partitioning the samples of input variable for calculating the probability density function(PDF). The proposed method has been applied to 2 problems for selecting the input variables, which are the 7 artificial signals of 500 samples and the 24 environmental pollution signals of 55 samples, respectively The experimental results show that the proposed methods has a fast and accurate selection performance. The proposed method has also respectively better performance than AP-MI estimation without the FP-ICA and regular partition MI estimation.