Objectives: This study was carried out to find the immune responses of the Gami-sopunghwalhyeol-tang $(Ji{={a}}w{`{e}}i-sh{={u}}f{={e}}nghu{'{o}}xu{`{e}}-tang)$ (hereinafter referred to GSHT) to the human fibroblast-like synoviocytes (hFLSs) isolated from patients with rheumatoid arthritis. Methods: Experiments were performed to measure the cytotoxity against hFCs and the production of pro-inflammatory cytokines in hFLSs and the production of NO, ROS. Results: 1. The gene expression of TNF-a, IL-6, IL-8 in hFLSs was effectively reduced at $100{mu}g/ml$, whereas IL-1 $eta$ was effectively reduced at 100 and $10{mu}g/ml$ of GSHT. 2. The gene expression of ICAM-1, MMP-3 in hFLSs was effectively inhibited at 100 and $10{mu}g/ml$ of GSHT, whereas TIMP-1 was effectively increased at 100 and $10{mu}g/ml$ of GSHT. 3. The gene expression of NOS-II in hFLSs was effectively inhibited at $100{mu}g/ml$ of GSHT. 4. The production of NO and ROS in hFLSs was inhibited at 100 and $10{mu}g/ml$ of GSHT. 5. The proliferation of hFLSs was significantly inhibited at $100{mu}g/ml$ of GSHT. Conclusions: Comparison of the results for this study showed that Gami-sopunghwalhyeol-tang ($Ji{={a}}w{`{e}}i-sh{={u}}f{={e}}nghu{'{o}}xu{`{e}}-tang$: GSHT) had immunomodulatory effects of suppressing or enhancing.