In this paper, an experimental real-time hybrid method, which implements the earthquake response control of a building structure with a TLD(Tuned Liquid Damper) by using only a TLD as an experimental part, is proposed and is experimentally verified through a shaking table test. In the proposed methodology, the whole building structure with a TLD is divided into the upper TLD and the lower structural parts as experimental and numerical substructures, respectively. The control force acting between their interface is measured with a shear-type load-cell which is mounted on the shaking table. The shaking table vibrates the upper experimental TLD with the response calculated from the numerical substructure, which is subjected to the excitations of the measured interface control force at its top story and an earthquake input at its base. The experimental results show that the conventional method, in which both a TLD and a building structure model are physically manufactured and are tested, can be replaced by the proposed methodology with a simple experimental installation and a good accuracy for evaluating the control performance of a TLD.