Cyclopia is a congenital ocular abnormality in which two orbits are fused together due to an arrest in the normal process of embryonic tissue development. Reported here is a case of cyclopia in a calf observed from the uterus of cow slaughtered in an abattoir in Korea on March 24, 2004. The calf possessed a spherical-shaped head and only one centrally placed eye. The one eyeball showed complete eyelashes on the defective eyelids. The nasal region and the anterior nares were absent along with a dorsally curved mandible extended beyond the defective maxillae.