A systematic methodology has been proposed to establish a reliable design of water pump system. A simplified steady-state dynamic model of water pump system has been developed to study the response of water pump system to the dynamic load mainly due to the run-out and unbalance. Design modifications are needed to strengthen the structural integrity of existing designs. Increasing the natural frequency of system is pursued to prevent a resonance from occurring in the engine excitation range. A computational reliability methodology combined with finite element analysis is used to identify the most significant factor affecting the system performance. This method considered influence of design control parameters for the performance of design. By including control factors to the system model in a systematic way, more reliable design is expected.