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Usefulness of $^{11}C-Methyl-L-and$ D-Methionine PET in Gliomas : with Special Attention to Recurrence
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  • Usefulness of $^{11}C-Methyl-L-and$ D-Methionine PET in Gliomas : with Special Attention to Recurrence
  • Usefulness of $^{11}C-Methyl-L-and$ D-Methionine PET in Gliomas : with Special Attention to Recurrence
저자명
Cho. Won-Sang,Kim. Chi-Heon,Kim. Jeong-Eun,Chung. June-Key,Paek. Sun-Ha,Jung. Hee-Won
간행물명
Journal of Korean neurosurgical society
권/호정보
2006년|39권 3호|pp.176-182 (7 pages)
발행정보
대한신경외과학회
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정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

Objective : This study concernes the usefulness of $^{11}C-methyl-L-and$ D-methionine[Met]-positron emission tomography[PET] for glioma grading and detection of recurrence in gliomas, compared with fluorine-18, 2-fluoro-deoxyglucose[FDG]-PET. Methods : Eighty patients underwent Met-PET study for evaluation of glioma : 37 astrocytomas [WHO grade II, 3; III, 8; IV, 26]. 27 oligodendrogliomas [WHO grade II, 16; III, 11]. and 12 suspicious recurrent gliomas. All images were taken within 2 weeks before operation. For suspicious recurrent cases on magnetic resonance images, both FDG-PET and Met-PET were performed. Results : In astrocytoma, Mean maximum standard uptake value[SUV] of region of interest[ROI] was not different between WHO grades [p=0.108]. but ROI/normal contralateral tissue SUV [T/N] ratio was statistically different between WHO grades [p=0.002]. T/N ratio was more closely related to visual scale than maximum SUV of ROI [p<0.001 and p=0.107 respectively]. In oligodendroglioma, there was no statistical difference between WHO grades in view of maximum SUV and T/N ratio. For recurrent gliomas, sensitivity of FDG-PET and Met-PET was 25% and 100%, while specificity of FDG-PET and Met-PET were 100% and 80%, respectively. Conclusion : Met-PET might be an appropriate tool for tumor grading in astrocytoma and be more sensitive for detection of recurrence in gliomas than FDG-PET.