The characteristics about the pressure drop in microtubes have been investigated. The test tubes are the circular, seamless, stainless steel tubes with an inner diameter of 0.244, 0.430, and 0.792 mm, respectively. R-l34a was used as a test fluid. Early flow transition which has been reported in some previous studies is not found in single-phase flow pressure drop tests. The conventional theory between friction factor and Reynolds number predicted the experimental friction factors within an absolute average deviation of $8.9\%$. The two-phase flow pressure drop increases for higher quality and mass flux, and for reduced inner diameter. The existing correlations fail to predict the experimental data. A new correlation to predict the two-phase flow pressure drop is developed in the form of the Lockhart-Martinelli correlation. The effects of the tube diameter and the surface tension were considered, and the correlation predicted the experimental data within an average absolute deviation of $8.1\%$.