Purpose: This study was to identify the relationship between clinical stress, self-efficacy, and self-esteem of nursing college students. Method: The data were collected from 172 nursing students in J city. Result: The average scores were; clinical stress 3.56/5, self-efficacy 3.52/5, and self-esteem 3.10/4. Clinical stress level was significantly different according to the general characteristics of clinical tutors(t=2.04, p=.043) and degree of clinical satisfaction(F=6.44, p=.002). Self-efficacy level was significantly different according to the general characteristics of school grade(t=2.29, p=.023) and degree of nursing major satisfaction(F=5.00, p=.008). Self-esteem level was significantly different according to the general characteristics of degree of clinical satisfaction(F=6.56, p=.002) and degree of nursing major satisfaction(F=14.22, p=.000). Self-efficacy level and self-esteem level showed a statistically significant but low positive correlation(r=.171, p=.05). Conclusion: A strategy for development of clinical stress management program is needed for nursing students.