Purpose: To test whether a hope carries the influence of pain to health related quality of life in patients with cancer. Method: 114 cancer patients recruited with. Data were collected through the Visual analog Scale, the Herth Hope Index, and the SF-36 Standard Korean Version. Results: The results showed that the measurement variables (pain, hope and health-related quality of life) were all significantly interrelated. The results of MedGraph revealed that the full mediation effect of hope in the relation between pain and mental component summary of quality of life was significant. Conclusion: These results imply that hope need to be considered in planning intervention programs for the enhancement of quality of life in patients with cancer.