This paper describes the effect of the droplet breakup process on fire suppression using a water-mist system, which is considered as a alternative to sprinkler fire suppression system. In the evolution of the water-mist, the droplet breakup process is an important phenomenon because it may significantly affect the droplet evaporation rate. The Fire Dynamics Simulator (FDS, Ver. 4.0) code, which is widely used for the simulation of fire dynamics, is used for the present simulation, and it is modified to consider the droplet breakup phenomena. The Prediction by the modified code shows good agreement with experimental data for the temperature. The original FDS predicts higher temperature about $30^{circ}C$ than experimental data. From the results, it is concluded that the droplet breakup phenomena must be considered for more precise simulation of fire suppression process.