Reliability of the Railway signaling system which is safety critical is determined by reliability of hardware and software. Reliability of hardware is easily predicted and demonstrated through lots of different studies and environmental tests, while that of software is estimated by the iterative test outcomes so estimates of reliability will depend on the inputs. Combinations of inputs to and outputs from the software may be mostly combinatoric and therefore all the combinations could not be tested. As a result, it has been more important to calculate reliability by means of a simpler method. This paper identifies the reliability prediction equation applicable to reliability prediction for railway signaling system software, and performs the simulation of onboard equipment of automatic train control for high speed train to review reliability prediction and validity.