To evaluate the performance of ventilation system properly, the correlations among the ventilation rate, indoor air-quality and cooling/heating load should be analysed. In this study, simulation tool to analyze the performance of ventilation system was developed. The simulation tool is based on the TRNSYS and some modules to calculate concentration of pollutants with the operation of ventilation system and to decide the signal of ventilation system were newly developed in this study. And these modules coupled with building load and heating/cooling simulation modules. To verify the validity of developed simulation tool, comparison study between simulation and field study were accomplished. As results, the simulation tool developed in this study can be used to predict the performance of ventilation system with accuracy.