For the reliable prediction of spatial geotechnical data, a procedure to build the Geotechnical Information System (GTIS) based on geo-knowledge within the frame of GIS technology was developed by introducing a couple of new concepts of the extended area containing the study area and the additional site visit for acquiring surface geological data. To build the GTIS for Gyeongju as the case study of regional model application, intensive site investigations and pre-existing geotechnical data collections were performed and additional site visit was also carried out for acquiring surface geo-layer data in accordance with the developed procedure. Within the GTIS based on geo-knowledge for Gyeongiu area, the spatially distributed geo-layers across the extended area were predicted using the geostatistical kriging method and those for the study area were extracted. Furthermore, the spatial distribution maps for the thickess of geo-layers and the depth to bedrock were constructed for the practical use in geotechnical field. It was evaluated that the GTIS based on geo-knowledge developed in this study is superior to the conventional geotechnical GIS in terms of both the standard deviation and the geological expert judgment.