To improve maritime safety, it is very important not only to make safer design and operation but also to do proper response in case of maritime casualty. The large-scaled casualties will be caused by loss of structural strength and stability due to the progressive flooding and enlargement of damage by the effect of waves and wind. To prevent foundering and structural failure, the prediction of ship motion behavior of damaged ship in wave is necessary. This paper describes the motion behavior of damaged ship in waves through theoretical and experimental studies. A time domain theoretical model of damaged ship motions and accidental flooding, which can be applied to any type of ship or arrangement and considers the effects of flooding of compartments, has been developed. The model tests have been carried out in regular and irregular waves with different wave heights and directions in ship motion basin. Those were performed for three different damaged conditions such as engine room bottom damage, side shell damage and bow visor damage of a Ro-Ro ship. Comparison of theoretical and experimental results was performed.