This paper deals with auto-landing guidance system design applicable to Smart UAV(Unmanned Aerial Vehicle). The proposed guidance law generates horizontal position, velocity and altitude commands in the longitudinal channel and heading angle command in the lateral channel to track a predetermined trajectory for automatic landing. The longitudinal guidance commands are derived from an approximated dynamic equations in vertical plane. These longitudinal guidance commands are appropriately distributed to each control input as the flight mode of Smart UAV is changed. The concept of VOR(VHF Omni-directional Range) guidance system is applied to generate the required heading angle commands to eliminate the lateral deviation from the desired trajectory. The performance of the proposed guidance system for Smart UAV is evaluated using the nonlinear simulation. Simulation results show that the proposed guidance system for auto- landing provides good tracking performance along the predetermined landing trajectory.