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Selection and Characterization of Peptides Specifically Binding to $TiO_2$ Nanoparticles
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  • Selection and Characterization of Peptides Specifically Binding to $TiO_2$ Nanoparticles
  • Selection and Characterization of Peptides Specifically Binding to $TiO_2$ Nanoparticles
저자명
Seo. Min-Hee,Lee. Jong-Ho,Kim. Min-Soo,Chae. Hee-K.,Myung. Hee-Joon
간행물명
Journal of microbiology and biotechnology
권/호정보
2006년|16권 2호|pp.303-307 (5 pages)
발행정보
한국미생물생명공학회
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정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

We have screened phage display peptide libraries to select for peptides binding to various sized $TiO_2$ nanoparticles. Phage libraries displaying random 7mer, 12mer, and C-7-Cmer peptides were used for screening. The size of target $TiO_2$ particles used were 7 nm, 15 nm, and 25 nm in diameter. We could select peptides binding each nanoparticles from all 3 libraries. Their binding was confirmed by transmission electron microscopy (TEM). Each peptide investigated was also shown to bind the other sized particles, meaning that the binding was specific for the nature of the particle rather than for the size of it. One of the 7mer peptides (PEP9, SVSPISH) was chosen for further analysis. The binding was shown to be in a dose-dependent manner, suggesting a specific interaction.