The overall performance and local flow fields of the fan, heat sink, and fan-sink were experimentally and numerically studied to investigate the flow characteristics of a fan-sink. The flow resistance of the heat sink was measured by small fan tester based on AMCA standards and compared with the CFD results to select available cooling fan for the fan-sink. The nonuniform velocity profile behind the fan outlet was shown by the flow visualization. The effects of nonuniform velocities on the performance of heat sink were discussed. To validate the commercial CFD code CFX-5.6, the predicted performance curve was compared with that of fan testing. The local flow fields of the fan-sink were analyzed by CFD results. MFR (multiple frame of reference) was used as a computational model combining rotating fan and stationary heat sink. Through the CFD results of the fan-sink, the flow patterns behind the fan outlet influenced the flow resistance and overall performance of the heat sink.