Objectives : We investigated the effect of Dohongsamul-tang (DHSMT) on the production of various cytokines in lipopolysaccaride (LPS) stimulated peripheral mononuclear cells (PBMCs) from CI patients. Methods: Cell viability was determined using MTT assay. ELISA was carried out for investigating $TNF-{alpha}$, $IL-1{eta}$, IL-6, IL-8, IL-4, and $TGF-{eta}$ 1 Results : The amount of tumor necrosis factor (TNF)-${alpha}$, interleukin (IL)-$1{eta}$, IL-6, IL-8, IL-4, and transforming growth factor(TGF)-${eta}$ 1 in PBMC culture supernatant significantly increased in the LPS treated cells compared to unstimulated cells. We show that DHSMT inhibited the production of TNF-${alpha}$, IL-1${eta}$, IL-6, IL-8, and IL-4 induced by LPS in a dose dependent manner. The maximal inhibition rate of the TNF-${alpha}$, IL-1${eta}$, IL-6, IL-8, and IL-4 production by pretreatment of DHSMT (1.0mg/ml) was 38.52 ${pm}$ 2.5% (P < 0.01), 44.02 ${pm}$ 3.5% (P < 0.05), 45.32 ${pm}$ 2.3% (P < 0.01), 42.30 ${pm}$ 3.1% (P < 0.05), and 49.70　${pm}$　3.1%(P ＆lt; 0.05), respectively. On the other hand, DMSMT significantly increased the LPS-induced TGF-${eta}$ 1 production(P<0.05). Conclusions : Taken together. these results suggest that DHSMT might have regulatory effects on cytokine production, which might explain its beneficial effect in the treatment of CI.