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Effects of Cirsium japonicum var. ussuriense Extract on Tumor Immunity
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  • Effects of Cirsium japonicum var. ussuriense Extract on Tumor Immunity
  • Effects of Cirsium japonicum var. ussuriense Extract on Tumor Immunity
저자명
Park. Mee-Ryung,Cho. Jung-Hyo,Yoo. Hwa-Seung,Son. Chang-Gue,Cho. Chong-Kwan,Lee. Yeon-Weol
간행물명
大韓韓醫學會誌
권/호정보
2006년|27권 4호|pp.30-47 (18 pages)
발행정보
대한한의학회
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정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Objective : The present study is aimed to elucidate the effects of Cirsium japonicum var. ussuriense on immunomodulation and the potential as an herbal remedy for cancer treatment. Method : It was performed through measurement of effects Cirsium japonicum var. ussuriense extract (CJE) on NO production, NK cell cytotoxicity and cytokine gene expressions related with macrophage and NK cell activity. Result : 1. CJE did not show any direct cytotoxic effects on 7250, HT1080, Hep G2 and CT-26 cells. 2. CJE activated macrophages partially to product NO and up-regulated gene expressions for iNOS in RAW 264.7 cells. 3. CJE promoted cytotoxicity of NK cells against YAC-1 cells at higher concentration than 200 ${mu}g/ml$. 4. CJE up-regulated gene expressions for $IL-1{eta}$, IL-2, iNOS, $IFN-{gamma}$ and $TNF-{alpha}$ in mice splenocytes. 5. CJE inhibited lung tumor metastasis induced by CT-26 cell transplantation compared with the control group. Conclusion : It could be concluded that CJE is an effective herbal drug for immune modulating and anti-cancer treatment by promoting activity of macrophages and NK cells.