Reliability Based Design Optimization(RBDO) is one of the optimization methods that minimize the product failure due to small changes of operating conditions or process errors. It searches the optimum that satisfies the safety margin of each constraint, and it gives stable and reliable designs. However, RBDO requires many times oj computational efforts compared with the conventional deterministic optimization(DO) to evaluate the probability of failure about each constraint, therefore it is hard to apply directly to large-scaled problems such as a flexible wing shape design optimization. For the efficient reliability analysis, the approximate reliability analysis method with the two-point approximation(TPA) is proposed In this study, the lift-to-drag ratio maximization designs are performed with 3-dimensional Navier-Stokes analysis and NASTRAN structural analysis, and the optimization results about the deterministic, FORM and SORM are compared.