Pressure drops and friction factors in square channels with twisted tape inserts plus axial interrupted ribs are investigated. Tests are performed for Reynolds numbers ranging from 8,900 to 29,000. The rib height-to-channel hydraulic diameter, $e/D_h$, is kept at 0.057 and test section length-to-hydraulic diameter, $L/D_h$ is 30. The pressure drops and friction factor values are enhanced with axial interrupted ribs and twisted tape inserts. Square channels with twisted tape inserts plus axial interrupted ribs show the greatest pressure loss penalty in the present work. Friction factor data obtained for the square channel with twisted tape inserts plus axial interrupted ribs are less than those in the past publications for circular tubes with axial interrupted ribs and twisted tape inserts.