A Genetic Algorithm (hereinafter GA) based optimum design algorithm and program for plane steel frames with partially restrained connections is presented. The algorithm was incorporated with the refined plastic hinge analysis method, in which geometric nonlinearity was considered by using the stability functions of beam-column members and material nonlinearity was considered by using the gradual stiffness degradation model that included the effects of residual stress, moment redistribution by the occurrence of plastic hinges, partially restrained connections, and the geometric imperfection of members. In the genetic algorithm, a tournament selection method and micro-GAs were employed. The fitness function for the genetic algorithm was expressed as an unconstrained function composed of objective and penalty functions. The objective and penalty functions were expressed, respectively, as the weight of steel frames and the constraint functions which account for the requirements of load-carrying capacity, serviceability, ductility, and construction workability. To verify the appropriateness of the present method, the optimum design results of two plane steel frames with fully and partially restrained connections were compared.