The evolution process of an initially homogeneous bone structure under axial and transverse loads is investigated in this paper. The external loads include axial and external lateral pressure, electric, magnetic and thermal loads. The theoretical predictions of evolution processes are made based on the adaptive elasticity formulation and coupled thermo-magneto-electro-elastic theory. The adaptive elastic body, which is a model for living bone diaphysis, is assumed to be homogeneous in its anisotropic properties and its density. The principal result of this paper is determination of the evolution process of the initially homogeneous body to a transversely inhomogeneous body under the influence of the inhomogeneous stress state.