Hangzhou Bay Bridge spans the Hangzhou Bay and is located at Zhejiang province in the southeast seacoast of China. The total length of the bridge is 36 km. The bridge is composed of bridge approaches made up of multi-span prestressed concrete box girders and two cable-stayed bridges over the north and south navigable spans respectively. The seismic response analysis of the bridge model shows that if the navigable spans are designed as the routine earthquake-resistance system, the displacements and internal forces in pylons, piers and deckes are too large to satisfy the anti-seismic requirement of the structure. Therefore, the seismic reduction design was carried out by using viscous dampers to dissipate the kinetic energy of the structure both longitudinally and transversely. Using the vibration reduction system and aiming at the reasonable optimal goal, the purpose to reduce the seismic responses in south and north navigable spans has been achieved.